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Selank, for example, demonstrates anxiolytic effects comparable to benzodiazepines in clinical studies without the sedation, amnesia, or dependence that make benzodiazepines problematic for long-term use

Most available evidence comes from laboratory and animal studies

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A study with 60 subjects with coronary artery disease investigated Pycnogenol s effects on microcirculation and platelet function

In addition, CAT deficiency in the DS group rendered the renal tissues more susceptible to oxidative injury and renal fibrosis (Kobayashi et al., 2005)