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doi:10.1016/s0022-3476(88)80114-8

Not everyone who wants to lose weight is a suitable candidate for GLP-1 medications

To date, there is no evidence of hepatotoxicity, nephrotoxicity, or cardiac damage in any animal trialseven when administered in extremely high doses

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In addition, low IGF-1 subjects in a study were found to possess up-regulated fatty acid metabolism along with down-regulated GLUT-1 gene (in charge of glucose uptake in erythrocytes, brain endothelial cells, eye, peripheral nerve and also responsible for materno-placental glucose transfer) [210]

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