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doi: 10.1124/jpet.114.218735

Lincoff AM, Botros J, Wolski K, et al

This cutting-edge peptide offers exciting possibilities for equine sports medicine and optimization

1999;274(39):27891-27897.[DOI] 7

6 Therefore, the production of NAPQI, in excess of an adequate store of conjugating glutathione in the liver tissue, is associated with hepatocellular damage, necrosis, and hepatic failure

Three small-molecule inhibitors targeting glutathione metabolism were tested in HCT-116 cells: CB-839 (glutaminase inhibitor), IKE (xCT transporter inhibitor), and Polydatin (glucose-6-phosphate dehydrogenase inhibitor)