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MOTS-c half-life is approximately 2 to 4 hours, but the downstream cellular effects (mitochondrial biogenesis, gene expression changes) persist well beyond serum clearance

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doi: 10.2337/dc06-2375

Direct cellular effects of some mediators, hormones and growth factor-like agents on denervated (isolated) rat gastric mucosal cells

It is widely believed that methylphenidate produces its therapeutic effects in ADHD by increasing dopamine level, which is similar to the actions of TAT-DAT NT as supported the microdialysis data (Fig