Dissolving 0.33g of Fmoc-His-Aib-OSu crude product and 1g of Boc protected Arg34GLP-1 (9-37) in 20mL of N, N-dimethylformamide, adding 2mL of N, N-diisopropylethylamine, reacting at room temperature for 8h, adding 20mL of mixed solution of methyl tert-ether and petroleum ether, precipitating and centrifuging to obtain Fmoc-GLP-1 (Lys-Lys) 20 Boc), the crude product was added to a trifluoroacetic acid solution, stirred at low temperature for 2 hours, 400mL of methyl-tert-ether was added, centrifugation was performed to obtain 0.98g of a solid, the crude product was dissolved in 20mL of N, N-dimethylformamide and 2mL of N, N-diisopropylethylamine was added, 0.33g of the side chain of compound 1 was dissolved in 2mL of N, N-dimethylformamide, slowly added dropwise to the reaction solution, reacted at room temperature for 2 to 3 hours, added to 400mL of a mixed solution of methyl-tert-ether and petroleum ether, centrifuged to obtain a solid, the above solid was added to 4mL of a 20% piperidine DMF solution, reacted at room temperature for 1 hour, and 40mL of a mixed solution of methyl-tert-ether and petroleum ether was added, centrifuged to obtain a solid, the above solid was added to 10mL of a cleavage solution (TFA: TIS: DCM =95 2), reacted at room temperature for 2 to 4 hours, 100mL of a mixed solution of methyl-tert-ether and petroleum ether was added, centrifugation to obtain 0.8g of a solid having a purity of57.15%, the specific liquid phase map is shown in FIG
It promotes skin regeneration by enhancing collagen production, improving tissue repair, and reducing inflammation
Intracellular diacylglycerols and oxidative stress are proposed to activate novel PKCs (nPKC) and/or JNK respectively, resulting in serine/threonine phosphorylation of IRS1
That is the standard starting dose
It has recently been described that enhanced band 3-aquaporin 1 interaction supports osmotic resistance, thereby reducing the tendency of hypo-osmotic burst and erythrocyte ACD
When should I seek medical help for GLP-1 side effects
