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Enhancing the GSH/GSSG ratio via overexpression of GSR or GCLC lowers ROS levels and confers protection against H 2 O 2 - or TNF-induced apoptosis 35,36

However, it was positively correlated with the expression of marker genes of vascular endothelial cells and fibroblasts and mitochondria-related genes (BCL2 and COX4l2)