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Such hyperandrogenemia has a deleterious impact on ovulation and metabolic function, promoting adiposity and insulin resistance 5

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In a phase 2 clinical trial, retatrutide demonstrated significant improvements in glycemic control and substantial weight loss in participants with type 2 diabetes over a 36-week period

More serious (but rare) risks include pancreatitis and gallbladder issues

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Kuna RS, Girada SB, Asalla S, Vallentyne J, Maddika S, Patterson JT, Smiley DL, DiMarchi RD, Mitra P: Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic ncreatic