Significant weight loss from tirzepatide may reduce levothyroxine requirements in some patients, necessitating TSH monitoring at baseline, after substantial weight loss, and every 6-12 months once stable
These somatotrophs constitute approximately 50% of the anterior pituitary cell population and are specialized for synthesis and secretion of growth hormone (GH, also called somatotropin), a 191-amino acid peptide hormone that is one of the most important regulators of growth, metabolism, and body composition
& Miller, L
I.CattiniP
What they found: Preventive administration: 70 to 85 % reduction in ulcer area Therapeutic administration: 60 to 75 % reduction And now the most interesting part: 10 ng/kg worked just as well as 10 g/kg Why it matters: If the molecule worked in a stoichiometric way (= simply blocking something piece by piece), a higher dose would necessarily produce a larger effect
The non-Th2 variant is frequently linked to smoking, age, and obesity
