[PubMed: 30689447] (70 year old woman developed seizures within 30 minutes after mistakenly taking an industrial form of ALA [4500 mg] with metabolic acidosis, lactic acidosis [14.9 mmoL], decrease in platelets [140,000 decreasing to 73,000/uL], and hemodynamic instability, responding to supportive therapy within several days)
Fructose is processed exclusively in the liver, and in excess, it is a primary driver of Non-Alcoholic Fatty Liver Disease (NAFLD)
Really the only Hashimotos patients who experience issues with goitrogens are those who are already deficient in iodine or those who are consuming massive quantities of goitrogenic compounds (this is rare)
It is primarily expressed in neurons of the cortex, cerebellum, and brainstem, with variable regional abundance, and shows more prominent localization in perivascular microglia and other components of the neurovascular unit, including endothelial cells, pericytes, and astrocytes (Pertwee, 2006)
For the first example, we will use the current and rated energy to calculate the C rate
Regeneron, Scholar Rock, and Lillys anabolic antibodies all block different components of the same pathway, the Activin Receptor Pathway
