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Important safety considerations include risk of pancreatitis (treatment should be discontinued if suspected), gallbladder disease, and potential worsening of diabetic retinopathy in patients with pre-existing retinopathy who experience rapid improvement in glucose control (particularly with semaglutide)

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Although these methods have demonstrated encouraging results in small-scale studies involving MS patients and EAE models, the absence of large-scale prospective randomized controlled trials means that these findings still suffer from limited reproducibility and challenges in generalizability across diverse populations

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Corroborating a functional role of GIPR, GLP-1GIPLani decreased body weight and food intake with increased efficacy compared with GLP-1Lani, but with equal efficacy to co-therapy of GLP-1Lani and a long-acting GIPR agonist (acyl-GIP) (Fig

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