This comprehensive screening revealed nine effective drugs: three antiviral drugs, four anticancer drugs, and two GSK-3 inhibitors 16,24,25
While MDA is widely recognized for its mutagenic properties, 4-HNE has more complex biological functions, acting as both a signaling molecule and a cytotoxic agent
This combined approach supports both energy metabolism and cellular defense simultaneously
In an experimental study with the use of human thyroid follicles isolated from normal paranodular tissue, it was observed that a high iodide dose (10 3 M) caused marked inhibition of radioiodine accumulation and organification process, as well as it induced necrosis of thyrocytes and ultrastructural lesions such as apical blebbing, cytoplasmic fragments desquamation, endoplasmic reticulum vesiculation, and accumulation of lipofuscin in secondary lysosomes [174]
This is still an emerging area of research, but its one of the more interesting potential effects of these medications
doi: 10.1016/j.fochms.2022.100155
