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From the gut to the brain: journey and pathophysiological effects of the food-associated trichothecene mycotoxin deoxynivalenol

McDonagh TA, Metra M, Adamo M, et al

There is also a risk that, because it promotes blood vessel generation, it might also speed the growth of tumors, if the user happens to already have one

de La Monte SM, Wands JR (2005) Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimers disease

Such trials hopefully will also identify whether lower doses might thus reduce even further any risks from initial and/or long-term use of such drugs. Not the RECOVER or Scripps trials, though

These receptors are highly expressed in the area postrema, nucleus tractus solitarius, and hypothalamus, brain regions critical for appetite regulation and energy homeostasis