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Active liver disease impairs copper clearance and increases the risk of copper accumulation

That rules out, straightforwardly, radioligand or fluorescent binding assays, competition binding against a known ligand, recombinant receptor-expressing lines, functional readouts tied to a defined coupling pathway, and antagonist controls to demonstrate that an effect is receptor-mediated

More water = lower concentration = easier to measure small doses

Biotin-responsive basal ganglia disease: a novel entity

Facet joint and arthritic back pain Facet joints connect vertebrae and allow spinal movement