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Consequently, the numbers of commensal obligate anaerobes, including Clostridia and Bacteroidia , are reduced due to elevated oxygen concentrations in the intestinal mucosa, which increases the risk of enteric infection (Winter et al

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NICE emphasises that pharmacological interventions must be combined with behavioural and lifestyle support

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CINCA/NOMID manifests early in life with a non-pruritic rash, aseptic meningitis, deforming arthropathy, skeletal abnormalities, and distinctive facial features such as frontal bossing and saddle-nose deformity (70)

Both are expected to deliver top-line results around the middle of 2026