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It is important to look at the context of this warning: Animal Studies: The warning is based on studies in rats and mice, where long-term exposure to these drugs led to the development of medullary thyroid carcinoma (MTC)

COMPETING INTERESTS JST reports receiving an investigator-initiated grant, on behalf of the University of Pennsylvania, from Novo Nordisk and receiving consulting fees from Currax Pharmaceuticals, LLC

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Quality assessment of the studies included Assessment of methodological quality for each study followed the Animal Research: Reporting of In Vivo Experiments 2.0 (ARRIVE 2.0) guidelines [24]

The LASSS-stimulated mechanism is un-related to prevention of HGF nitration because all of the findings (shown in Figure 1e right panel, bars 810 and Figure 2a) were obtained under nitration-free conditions (omitting peroxynitrite treatment)