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This may be relevant for sleep disrupted by systemic inflammation Stress-Related Sleep Disruption DSIP DSIP has been shown to suppress stress-induced cortisol and ACTH elevation, which may address stress-related sleep onset difficulties

Impact of heparanase on renal fibrosis

Drugs 18 , 639 (2020)

Compared to other organs, it consumes more oxygen, generates more free radicals, and has lower levels of antioxidants, making it more susceptible to damage from oxidative stress (96)