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in vitro pituitary cells
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Drugs like semaglutide (sold as Ozempic and Wegovy) and tirzepatide (Mounjaro) mimic the action of natural GLP-1 but last far longer in the body
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These changes of the a-loop conformation allow the substrate and ATP access, further increasing the intrinsic TK activity towards phosphorylation of other tyrosines in the receptor and subsequently of exogenous substrate proteins
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