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Methods Study approval All the related experiments and protocols used in these studies were approved by the Ethical Committees of the University of Cordoba and Junta de Andalusia (Spain), according to EU normative for the use and care of experimental animals (EU Directive 2010/63/UE, September 2010)

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Conversely, as drug pressure subsides or microenvironmental cues shift, DTPs can reactivate stemness programs and re-enter the cell cycle, giving rise to relapsed tumors [82]