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The same may be true for insulin potentiation therapy

Mood Shifts, Low Libido, and Brain Fog Elevated prolactin suppresses estrogen, and low estrogen drives depression, poor libido, brain fog, and emotional flatness

(WHO International Agency for Research on Cancer Monograph Working Group) (August 2009)

Patients who took GLP-1 agonists for diabetes and weight loss experienced improvements in depressive symptoms, although the patients in those trials did not have clinical depression