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Most recently, PAGln levels were positively associated with heart failure, independent of ejection fraction, and shown to have mechanistic links to relevant CV phenotypes in several studies 12

Oller-Salvia, B., Sanchez-Navarro, M., Giralt, E

doi: 10.1016/j.jaad.2006.06.017 57 MeletiMMooiWJCasparieMKvan der WaalI

according to the latest meta-analysis including over 11 million patients, the rate for the world population is 1 : 313, but in patients with ischaemic heart disease the incidence is 10 times higher (1 : 31), with premature ischaemic heart disease 20 times (1 : 15), and in those with severe hypercholesterolaemia, 23 times higher (1 : 14) [276]

(3-, 5-, 4,5--) 10-20% ,