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Still, it typically takes several months to observe significant weight loss

The Particle Mesh Ewald (PME) method was used to treat all electrostatic interactions beyond a cutoff of 10 and the bonds involving hydrogen atoms were constrained using the LINCS algorithm 60

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Laboratory findings were consistent with rhabdomyolysis and normalized within 4 days following discontinuation of tirzepatide and initiation of supportive intravenous fluid therapy