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Consistent site rotation is important primarily to reduce the risk of local reactions rather than for absorption concerns

Testing rather than guessing provides the clearest guidance

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Underlying conditions that can impair treatment response include hypothyroidism, polycystic ovary syndrome (PCOS), Cushing's syndrome, obstructive sleep apnea, and psychiatric conditions like binge eating disorder

Some people find this more comfortable because the injection feels more substantial, while others prefer smaller volumes to minimize injection site reactions

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