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Therefore, the glycaemic improvement in animals treated with a GLP-1R/GcgR co-agonist is attributable to body-weight-independent and -dependent effects

Key highlights Semaglutide is an FDA-approved GLP-1 receptor agonist that is used to treat adults with type 2 diabetes mellitus and obesity

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Data availability The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request

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In addition to their heart-protective effects, GLP-1s have demonstrated anti-inflammatory properties and improved liver function, which correlate with improved biological aging markers (Celsa et al., 2025