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In local synovial tissues, the hypoxic environment favors stable expression of HIF-1, enhancing the survival of pathogenic CD4 + T cell and further aggravating inflammation (141, 151)

10.3389/frym.2019.00026 Front

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and The DPP-IV inhibitors, compounds that increase the concentration of endogenous incretins, including GLP-1, by limiting the proteolytic cleavage by DPP-IV

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