In anonymous complaints about Calibrate filed with the Federal Trade Commission and obtained via a Freedom of Information Act Request, one patient wrote: "I have regained half of what I originally lost, a setback representing about six months of work." Another customer said they started gaining weight back as soon as they stopped the medication cold turkey, so they got back on the medication by signing up for Calibrate's second-year program
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New GLP-1 medications like retatrutide , survodutide , and CagriSema may offer improved efficacy at competitive prices
Weight changes from GLP-1 therapy may require adjustment of levothyroxine doses, necessitating close thyroid function monitoring
52,53 In a phase 2, multi-center trial conducted at 45 centers, orforglipron at doses of 12 mg or greater showed significant reductions in HbA1c and bodyweight compared with placebo or dulaglutide
Patients with a BMI of 30, or a BMI of 27 with one weight-related medical condition (like high blood pressure or type 2 diabetes), are candidates for weight loss medications like GLP-1s
