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Indeed, the hypomethylation of CD40L in T cells has also been associated with increased disease activity in SLE patients (196, 197)

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Discontinuation rates were substantially reduced to 18.8% (95% CI 18.6, 19.0) at 1 year and 36.8% (95% CI 36.5, 37.1) at 3 years when using a grace period of 180 days, and to 28.8% (95% CI 28.5, 29.1) at 3 years when using a grace period of 365 days

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Overall, PYC exhibits robust antioxidant activity (Figure 1) in diverse contexts and experimental models