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Proglucagon is mainly expressed in the intestine, pancreas and hindbrain

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Mechanism of Action Retatrutide simultaneously activates three metabolic receptors, distinguishing it from dual agonists such as tirzepatide (GLP-1/GIP only) and single agonists such as semaglutide (GLP-1 only)

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However, this is early research, and more studies are needed to confirm these findings in larger and more diverse groups

Study participants either had rheumatoid arthritis or spondyloarthritis