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In the liver, it drives Phase II detoxification, binding to toxins, heavy metals and drug by-products and converting them into a form your body can flush out through bile and urine

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[DOI] [PubMed] [Google Scholar] Li C, Xi Y, Li S, Zhao Q, Cheng W, Wang Z, Zhong J, Niu X, Chen G (2015) Berberine ameliorates TNBS induced colitis by inhibiting inflammatory responses and Th1/Th17 differentiation

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So few documented side effects mainly reflects absence of rigorous data , not proof of safety