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As the main substrate of lipid peroxidation released from PL in the cell membrane, AA is a precursor of proinflammatory mediators that can be metabolized by cyclooxygenases (COX), ALOX, and CYP450 monooxygenases to synthesize biologically active inflammatory mediators, such as prostaglandins (PGs) and leukotrienes [91]

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Acquired GHD occurs due to injuries or damage to the hypothalamus or pituitary gland (e.g., via head trauma, infections, tumors, or treatments such as radiation therapy)

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