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Some people on GLP-1 medications do experience more serious side effects like bowel obstruction, gallstone attacks, or gastroparesis (a condition where your stomach muscles dont move food in the way they should)

Furthermore, NAMPT-mediated NAD + biosynthesis in the intestines and its upstream and downstream mediators, adenosine monophosphate-activated protein kinase (AMPK) and NAD + -dependent deacetylase sirtuins (SIRTs), respectively, are critical for intestinal homeostasis, including gut microbiota composition and bile acid metabolism, and GLP-1 production

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PMID: 41068996

90 mg: -1.02%, p=0.001), BW (45 mg: -3.51%, p=0.0019