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If a vial accidentally freezes, discard it rather than attempting to use it after thawing

These candidates typically include people who are less able to get B12 naturally from their diet

[PubMed] Filatova EV, Kasian A, Kolomin TA, Rybalkina EY, Alieva AK, Andreeva LA, Limborska SA, Myasoedov NF, Pavlova GV, Slominsky PA, Shadrina MI

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By blocking NNMT activity, it has been investigated for its influence on cellular metabolism