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As in 2026, the most effective GLP-1 for weight loss is tirzepatide or Zepbound
Combination formulations may also have different pH optima for each component, forcing a compromise pH that may not be ideal for either peptide individually
Practically: Strong recommendation to pursue: CME in obesity medicine (60+ hours for ABOM certification) Obesity Medicine Board Certification (ABOM) open to all physicians including psychiatrists Specialized training for NPs through organizations like American Association of Nurse Practitioners This training: Solidifies your competency if questioned Helps you navigate complex cases safely Improves patient outcomes (obesity treatment is more than just prescribing) What are the reimbursement rates for weight management visits
Just like any pharmaceutical medication, there are side effects and disclaimers
High-fiber foods that you should avoid include: Whole-grain breads, oatmeal/cereals, granola Nuts, seeds, raw/dried vegetables or fruit (NO salads) Beverages with pulp Nutritional supplements that contain fiber Pepper, beans, corn/popcorn Foods that you may eat include: Cream of wheat/grits, white rice, refined pastas/noodles Cooked fresh/canned vegetables and vegetables without seeds including asparagus, beets, carrots, mushrooms, green beans, potatoes without skin Bananas, soft cantaloupe, honeydew, avocado Chicken, fish, beef, pork, tofu, eggs Margarine, butters/oils, smooth sauces and dressings Cakes, cookies, pudding, ice cream without nuts or seeds, hard candy, popsicles, yogurt, and cheese Beginning one full day before your procedure , you must begin a clear liquid diet, which means that you should NOT eat any solid foods and should ONLY drink clear liquids
These advantages make semaglutide especially effective for T2DM patients with pre-existing cardiovascular conditions [9, 13]
