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Hydrogel loading and release of selected drug candidates was examined using UV-visible spectrometry

Lancet Diabetes Endocrinol 4(6):537547

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On/off cycling here is driven by caution, not by tolerance data: because there is no long-term human safety record, building in scheduled off periods is the conservative research default

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Clinical studies in the US show patients could lose an average of 17% of their starting weight (22% in early responders) over 64 weeks