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To achieve a plasma level of 0.7mM (less than the 1mM used int he paper), you have to give a rat 150mg/kg/day IV, which is the equivalent of a 1451mg IV SAMe daily dose to a 60kg human, but since the oral absorption is around 5%, that's the equivalent of more than a 29,000mg daily oral dose

Why Are Vitamin B12 Injections Needed

Research subjects typically administer 0.1 to 0.3 mg via subcutaneous injection 30 to 60 minutes before bedtime, with cycles running 4 to 8 weeks followed by a break period