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As a reference, recombinant IGF-1 injections have a half-life of under 6 hours when given subcutaneously as a treatment of growth failure and slower development of children due to poor IGF-1 levels

[0008] In order to achieve the above objects of the present invention, the following technical solutions are provided: [0009] The present invention provides a preparation method of Semaglutide, comprising the steps of: step 1: coupling Gly to a resin by solid phase synthesis to obtain Gly-resin