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* The frequency of side effects is based on clinical trial data and post-marketing surveillance

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1 Several antidepressant medications are known to increase systemic levels of serotonin, including monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), some opioids, antihistamines, serotonin-releasing illicit drugs, and over-the-counter herbal medications 1 (Figure 1)

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Importantly, an additional experiment showed that LASSS-treated BSA (after the removal of un-reacted LASSS) exhibited nitration resistance to the optimal peroxynitrite-treatment (1:2000 ratio), as shown in supplementary Figure 2, suggesting a model that LASSS-induced chemical modification mechanism exerts a nitration-inhibitory effect on a wide range of proteins susceptible to tyrosine nitration

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