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To advance translational applications, future studies should focus on: (1) transforming dynamic biomarkers into clinical decision-making tools, such as evaluating early changes in circulating mitochondrial-derived vesicles or oxidative stress markers (e.g., 8isoprostaglandin F2 (8-iso-PGF2))to predict subsequent biochemical and histological responses

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The data validation process included: Standardization of units (currency conversions, volume units, inflation adjustments) Cross-verification of data points across multiple secondary sources Normalization of inconsistent datasets Identification and resolution of data gaps Outlier detection and removal through algorithmic and manual checks Plausibility and coherence checks across segments and geographies This ensured that the dataset used for modelling was clean, robust, and reliable