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The result is a catch-22: patients must persist long enough to demonstrate clinical benefit, yet the financial burden often prevents that persistence, undermining the very outcomes needed to justify reimbursement

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As scientists continue to push forward with new drugs and grapple with questions about what exactly these drugs are doing, Jakicic hopes that everyone remembers one important truth: Muscle health is very different from muscle volume. When voluntarily losing weight, the goal should not be to preserve muscle mass entirely, but rather to limit unnecessary muscle loss and improve muscle function

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