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The Kyn/Trp ratio was also directionally higher in symptomatic patients than in asymptomatic V30M carriers, although this comparison did not reach statistical significance in the two-tailed analysis ( p = 0.0594)

Journal of Medicinal Chemistry

This small chemical change makes a big difference

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M.ParkH.KovalM.OrrM.ReedM.LiangY.et al (2009)