It identifies and neutralises free radicals, which are unstable molecules that can damage DNA, cell membranes, and proteins
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5 Shedding starts 2-3 months (6-12 weeks) after a trigger like rapid weight loss from GLP-1 drugs, peaks for 2-4 months , then slows as new anagen hairs emerge
Pfizer terminated lotiglipron in October 2023 due to dose-dependent liver enzyme elevations, and subsequently discontinued danuglipron in April 2025 after a single case of potential drug-induced liver injury was identified in a dose-optimization study
For context, the broader class also includes the GIP/GLP-1 dual agonist tirzepatide, studied in SURMOUNT (NEJM 2022) and SURMOUNT-OSA (NEJM 2024), plus other GLP-1 receptor agonists like liraglutide and dulaglutide