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But the authors appropriately noted limitations: the retrospective design, small sample size, and the fact that most patients were already in remission when starting therapy

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Sublingual drops lack this dosing precision because bioavailability is unpredictable

The whole batch becomes one homogenized solution, mixed non-stop, then machine-filled to the exact same dose so the last vial matches the first

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Dysesthesia signal (Phase 3) TRIUMPH-4 topline results, released December 11, 2025, reported dysesthesia in about 20.9% of participants at the highest dose