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The early deterioration of diabetic retinopathy observed with GLP-1 RAs may reflect rapid glucose decline that affects osmotic pressure rather than direct retinal toxicity [91]

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In terms of kidney function, while the initial eGFR for GLP-1 RAs users was notably lower, the difference was no longer significant by the D60-90 interval, hinting at a possible stabilization or amelioration in kidney function attributed to GLP-1 RAs therapy (Figure S2)

Activation of GLP-1R in these cells can be monitored by measuring luciferase activity