glp-1 vs sglt2 weight loss Agonists vs. Inhibitors: Best Practices for Type 2 Diabetes Care GLP1 Receptor Agonists vs SGLT2-I

GLP-1 appears more important for appetite suppression and probably drives the majority of weight loss effect

K-18 is released during hepatocyte apoptosis and has been proposed as a marker of cell death in the liver 31

And its not something you can manufacture by willpower alone. The clinicians we spoke with unanimously agree that GLP-1s generally should be taken for life

Because the drugs slow down digestion, food can ferment in the stomach, leading to a build up of hydrogen sulfide

Experts warn that over time, these drugs may blunt the body's own GLP-1 production

Tirzepatide showed a noninferior reduction in all-cause mortality (HR 0.88, 95% CI 0.68 to 1.16), myocardial infarction (HR 0.91, 95% CI 0.73 to 1.12) and stroke (HR 0.78, 95% CI 0.59 to 1.03) compared to dulaglutide, although CIs remained compatible with no difference