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Cons: Low absorption (1020%) means you often need significantly higher doses to achieve comparable injectable effects

What is missing There is no published human pharmacokinetic study of subcutaneous AOD-9604, no published human topical or intranasal exposure data, no Phase 3 efficacy trial, no long-term safety data beyond 24 weeks, and no published human cartilage or joint outcome data

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NAD also serves as a substrate for several enzyme families that trigger critical cellular processes