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Huadong Pharmaceutical has appealed this ruling but on 31 December 2025, the Supreme Peoples Court in China made a positive decision concerning the intellectual property rights relating to the semaglutide compound patent, and upheld the Beijing IP Court ruling, recognizing the validity of the semaglutide compound patent, until 20 March 2026

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Theres also likely a hormonal factor: Youre losing facial fat, which acts as an endocrine organ, producing hormones like oestrogen, and oestrogen is important to the integrity of your skin, says Dr

Those using any diabetic medication should be closely monitored by their physician, who can determine if they should discontinue use

Another observation the researchers made that stands out is that CJC-1295 may have led to an increase in total pituitary RNA and GH mRNA