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HIF-1 is activated due to blockade of its degradation pathway mediated by low oxygen levels, thereby increasing the expression of target genes, including those encoding glycolytic enzymes and glucose transporters, and increasing lactate secretion 67

Unfused roGFP2 served as negative and roGFP2 fused to homo sapiens glutaredoxin (roGFP2- Hs Grx) as positive control for direct interaction with GSSG

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doi: 10.3760/cma.j.issn.2095-4255.2017.11.019 116

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