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doi: 10.1210/jc.2002-020656 181 FizaziKYangJPelegSSikesCRKreimannELDalianiDet al
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Unused pens typically require refrigeration, while in-use pens often stay stable at room temperature
47,48 Dysregulated inflammatory signaling by fat tissue and release of growth factors, cytokines, and free radicals from the ovaries, liver, and other tissues contribute to the inflammatory state and promote further metabolic imbalance and insulin resistance