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Clinically significant portal hypertension events were defined as the first occurrence of esophageal varices (i.e., with and without bleeding), gastric varices, ascites, hepatic failure, hepatorenal syndrome, portal hypertension, liver transplant status, fibrosis and cirrhosis of liver, hepatic encephalopathy, jaundice, and chronic passive congestion of liver

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In preclinical and cell culture research, KPV demonstrates suppression of pro-inflammatory cytokines IL-6, IL-1, and TNF- through melanocortin receptor pathway activation