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As cheaper versions become widely available, adherence and continuity of care could become major concerns

Again, this factor is limited by patient insight (the hardest thing to get across in treating melasma)

Chrysophanol attenuates Hepatitis B virus X protein-induced hepatic stellate cell fibrosis by regulating endoplasmic reticulum stress and ferroptosis

In the SUSTAIN clinical trial program, cases of pancreatitis were reported, but at rates that did not reach statistical significance in most individual studies when compared to control groups

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