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Abstract Glutamine (Gln) metabolism serves dual metabolic roles: it fuels the tricarboxylic acid (TCA) cycle, while concurrently sustaining redox balance through glutathione (GSH) synthesis
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Although it has a powerful physiological function, more studies have focused on its pathological role, mainly because it is involved in the pathogenesis of several neurodegenerative diseases, such as Parkinsons disease (PD) and dementia of Lewy body (DLB) [7, 8]
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That said, 9 of the 24 cytoplasm-localised sequences do encode a peroxisomal targeting signal, whilst 10 sequences encode a nuclear targeting signal (Supplementary file 3)